解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Stress granule (SG)-like antiviral granules (AVG) had been found in some vaccinia virus infection conditions and shown to repress translation. Similar RNA granules are also associated with translational inhibition and poxvirus restriction mediated by the host restriction factor SAMD9, but their function is less clear....
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.01.007
更新日期:2019-03-01 00:00:00
abstract::Hepatitis C virus (HCV) was shown to activate protein kinase R (PKR), which inhibits expression of interferon (IFN) and IFN-stimulated genes by controlling the translation of newly transcribed mRNAs. However, it is unknown exactly how HCV activates PKR. To address the molecular mechanism(s) of PKR activation mediated ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.01.024
更新日期:2019-03-01 00:00:00
abstract::The genus Badnavirus is characterized by members that are genetically and serologically heterogeneous which presents challenges for their detection and characterization. The presence of integrated badnavirus-like sequences in some host species further complicates detection using PCR-based protocols. To address these c...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.01.013
更新日期:2019-03-01 00:00:00
abstract::Tobacco mosaic virus (TMV) is widespread in China and causes considerable economic losses to tobacco production. The molecular epidemiology of this virus is, however, poorly understood. In this study, we sequenced the genomes of 51 TMV isolates from five tobacco-producing regions in China and investigated the dispersa...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.12.001
更新日期:2019-02-01 00:00:00
abstract::Human parainfluenza virus type 2 phosphoprotein (P) is an essential component of viral polymerase. The P gene encodes both P and accessory V proteins by a specific gene editing mechanism. Therefore, the N-terminal 164 amino acids of P protein are common to V protein. Interestingly, while P protein is located in the cy...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.12.005
更新日期:2019-02-01 00:00:00
abstract::Glycoprotein D (gD) of herpes simplex virus type 1 (HSV-1) plays a key role in multiple events during infection including virus entry, cell-to-cell spread, and virus-induced syncytia formation. Here, we provide evidence that an arginine/lysine cluster located at the transmembrane-cytoplasm interface of gD critically c...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.09.018
更新日期:2019-01-15 00:00:00
abstract::To investigate the role of Tobacco vein banding mosaic virus (TVBMV) 3'-UTR in virus systemic infection, three types of deletions were introduced into TVBMV infectious clone pCaTVBMV-GFP. Mutants with deletions at the nucleotide position 8-42, 43-141, or 163-174 in the 3'-UTR failed to cause systemic infection in N. b...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.11.001
更新日期:2019-01-15 00:00:00
abstract::The APOBEC3 enzyme family are host restriction factors that induce mutagenesis of HIV-1 proviral genomes through the deamination of cytosine to form uracil in nascent single-stranded (-)DNA. HIV-1 suppresses APOBEC3 activity through the HIV-1 protein Vif that induces APOBEC3 degradation. Here we compared two common po...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.11.004
更新日期:2019-01-15 00:00:00
abstract::Bombyx mori nucleopolyhedrovirus (BmNPV) orf11 (bm11) is a highly conserved gene with unknown function. It is homologous to AcMNPV orf19. In this study, a bm11 knockout virus was constructed and its role was investigated. Expression analysis indicated that bm11 is a late gene and confocal microscopy analysis demonstra...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.10.026
更新日期:2019-01-15 00:00:00
abstract::Highly pathogenic alphaviruses display complex glycans on their surface. These glycans play a crucial role in viral pathogenesis by facilitating glycan-host interaction during viral entry which can be targeted. Various studies have reported antiviral activity of lectins that bind to the glycans present on the surface ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.10.009
更新日期:2019-01-02 00:00:00
abstract::HIV-1 transmission is usually initiated by a single viral strain called transmitted/ founder (T/F) virus. In in vitro models, HIV-1 can efficiently spread via cell-free and virological synapse (VS)-mediated cell-to-cell infection. Both modes of infection require the viral glycoprotein Envelope (Env). The efficiency wi...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.10.016
更新日期:2019-01-02 00:00:00
abstract::Recombination is a driving force for the emergence, evolution and virulence/epidemics of viruses, comprising the Enterovirus genus of the Picornaviridae family, important for human and animal health. By analyzing 2949 complete genomes/coding sequences, we provide a thorough and up-to-date overview of the genome-wide p...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.10.006
更新日期:2019-01-02 00:00:00
abstract::In March 2017, a novel highly pathogenic avian influenza A(H7N9) virus was detected at two commercial broiler breeder facilities in Tennessee, United States. In this study, a wild bird low pathogenic avian influenza A virus, A/blue-winged teal/Wyoming/AH0099021/2016(H7N9), was shown to be the probable precursor of the...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.09.003
更新日期:2018-12-01 00:00:00
abstract::Potato virus S (PVS) is a major plant pathogen that causes considerable losses in global potato production. Knowledge of the evolutionary history and spatio-temporal dynamics of PVS is vital for developing sustainable management schemes. In this study, we investigated the phylodynamics of the virus by analysing 103 nu...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.09.022
更新日期:2018-12-01 00:00:00
abstract::The major capsid protein of HPV, L1, assembles into pentamers that form a T = 7 icosahedral particle, but the location of the co-assembled minor capsid protein, L2, remains controversial. Several researchers have developed useful monoclonal antibodies targeting L2, but most react with linear epitopes toward the N-term...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.08.017
更新日期:2018-11-01 00:00:00
abstract::We previously demonstrated that human parainfluenza virus type 2 (hPIV-2) induces RhoA activation, which promotes its growth. RhoA controls the equilibrium between globular and filamentous actin (F-actin). We found that F-actin formation is induced by wild type (wt) hPIV-2 infection, and that inhibition of F-actin for...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.08.015
更新日期:2018-11-01 00:00:00
abstract::ARGONAUTEs (notably AGO1 and AGO2) are effectors of plant antiviral RNA silencing. AGO1 was shown to be required for the temperature-dependent symptom recovery of Nicotiana benthamiana plants infected with tomato ringspot virus (isolate ToRSV-Rasp1) at 27 °C. In this study, we show that symptom recovery from isolate T...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.08.016
更新日期:2018-11-01 00:00:00
abstract::Rice tungro disease is caused by a complex of two viruses, Rice tungro bacilliform virus (RTBV) and Rice tungro spherical virus (RTSV). To examine the RNAi-based defence response in rice during tungro disease, we characterized the virus-derived small RNAs and miRNAs by Deep Sequencing. We found that, while 21 nt/22 nt...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.07.022
更新日期:2018-10-01 00:00:00
abstract::Metagenomic analysis of whole mosquitoes allows the genetic characterization of all associated viruses, including arboviruses and insect-specific viruses, plus those in their diet or infecting their parasites. We describe here the virome in mosquitoes, primarily Culex pipiens complex, Cx. tarsalis and Cx. erythrothora...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.07.029
更新日期:2018-10-01 00:00:00
abstract::Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) vFLIP, a latent gene of KSHV, was first identified as a FLICE-inhibitory protein (FLIP) protecting cells from apoptosis. The vFLIP protein has been shown to activate the NF-κB signaling involved in spindle morphology formation both in HUVECs infected with KSHV and Ka...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.07.007
更新日期:2018-09-01 00:00:00
abstract::Varicella zoster virus (VZV) is a neurotropic alphaherpesvirus that, following primary infection (varicella), establishes latency in sensory, autonomic, sympathetic and parasympathetic neurons, where it remains until reactivation (zoster). VZV-specific cell-mediated immune responses maintain VZV latency; thus, immunos...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.06.013
更新日期:2018-09-01 00:00:00
abstract::Tissues from Australian brushtail possums (Trichosurus vulpecula) that had been experimentally infected with wobbly possum disease (WPD) virus (WPDV) were examined to elucidate pathogenesis of WPDV infection. Mononuclear inflammatory cell infiltrates were present in livers, kidneys, salivary glands and brains of WPD-a...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.07.003
更新日期:2018-09-01 00:00:00
abstract::Sodium taurocholate cotransporting polypeptide (NTCP) is a functional receptor for human hepatitis B virus (HBV) and its satellite virus Hepatitis D virus (HDV). Physiologically, NTCP is responsible for the majority of sodium-dependent bile acids uptake by hepatocytes. The p.Ser267Phe (S267F) variant of NTCP is a sing...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.07.006
更新日期:2018-09-01 00:00:00
abstract::The papillomavirus (PV) E2 protein activates transcription and replication by recruiting cellular proteins and the E1 DNA helicase to their binding sites in the viral genome. We recently demonstrated that phosphorylation of tyrosine 102 in the bovine papillomavirus (BPV-1) E2 protein restricts these activities and tha...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.05.013
更新日期:2018-08-01 00:00:00
abstract::Transmissible gastroenteritis virus (TGEV) causes severe diarrhea and high mortality in newborn piglets. It is well established that porcine intestinal epithelium is the target of the TGEV infection, however the mechanism that TGEV invades the host epithelium remains largely unknown. Aminopeptidase N (APN) is a known ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.05.009
更新日期:2018-08-01 00:00:00
abstract::The V3 loop of the human immunodeficiency virus type 1 (HIV-1) gp120 exterior envelope glycoprotein (Env) becomes exposed after CD4 binding and contacts the coreceptor to mediate viral entry. Prior to CD4 engagement, a hydrophobic patch located at the tip of the V3 loop stabilizes the non-covalent association of gp120...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.06.005
更新日期:2018-08-01 00:00:00
abstract::HIV-1 virus entry into target cells requires the envelope glycoprotein (Env) to first bind the primary receptor, CD4 and subsequently the co-receptor. Antibody access to the co-receptor binding site (CoRbs) in the pre-receptor-engaged state, prior to cell attachment, remains poorly understood. Here, we have demonstrat...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.04.002
更新日期:2018-06-01 00:00:00
abstract::Adenovirus serotype 5 (Ad5) is a common cause of respiratory tract infection, and populations worldwide have high prevalence of anti-Ad5 antibodies, implying extensively prior infection. Ad5 infection potently activates the host innate defense and inflammation, but the molecular mechanisms are not completely clarified...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.04.005
更新日期:2018-06-01 00:00:00
abstract::The International Human Papillomavirus (HPV) Reference Center supports quality and order in HPV research and diagnostics. Notably, the center assigns HPV type numbers to novel HPV types, maintains a reference clone repository, and issues international proficiency panels for HPV genotyping. The established HPV types, c...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.04.003
更新日期:2018-06-01 00:00:00
abstract::Dipeptidyl peptidase 4 (DPP4) is a receptor for MERS-CoV. The soluble form of DPP4 (sDPP4) circulates systematically and can competitively inhibit MERS-CoV entry into host cells. Here, we measured the concentration of sDPP4 in the plasma and sputa of 14 MERS-CoV-infected patients of various degrees of disease severity...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.03.015
更新日期:2018-05-01 00:00:00
abstract::Classical swine fever virus (CSFV) nonstructural protein NS5A is a multifunctional protein functioning in regulation of viral genome replication, protein translation and assembly by interaction with viral or host proteins. Here, heat shock protein 27 (Hsp27) has been identified as a novel binding partner of NS5A by us...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.02.020
更新日期:2018-05-01 00:00:00
abstract::The management of hand-foot-and-mouth disease(HFMD) epidemic is difficult due to the frequent emergence of non-EV71 and non-CVA16 enteroviruses and some cases testing negative for HFMD-associated causative agents. To clarify the virus spectrum of mild and severe HFMD, a comprehensive virome analysis of 238 samples was...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.02.004
更新日期:2018-05-01 00:00:00
abstract::High Plains wheat mosaic virus (HPWMoV, genus Emaravirus; family Fimoviridae), transmitted by the wheat curl mite (Aceria tosichella Keifer), harbors a monocistronic octapartite single-stranded negative-sense RNA genome. In this study, putative proteins encoded by HPWMoV genomic RNAs 2-8 were screened for potential RN...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.02.013
更新日期:2018-05-01 00:00:00
abstract::During viral entry, enveloped viruses require the fusion of their lipid envelope with host cell membranes. For coronaviruses, this critical step is governed by the virally-encoded spike (S) protein, a class I viral fusion protein that has several unique features. Coronavirus entry is unusual in that it is often biphas...
journal_title:Virology
pub_type: 杂志文章,评审
doi:10.1016/j.virol.2017.12.015
更新日期:2018-04-01 00:00:00
abstract::Porcine epidemic diarrhea virus (PEDV) is a causative agent of porcine epidemic diarrhea (PED). PED, characterized by acute diarrhea, vomiting, dehydration, has caused serious economic losses in pig industry worldwide. Here, we demonstrate that activation of a disintergrin and metalloprotease 17 (ADAM17) induced the d...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.02.001
更新日期:2018-04-01 00:00:00
abstract::We reported previously that carbohydrate attachment to an overlapping glycosylation site adjacent to the signal peptide of GP3 from equine arteritis virus (EAV) prevents cleavage. Here we investigated whether this unusual processing scheme is a feature of GP3s of other Arteriviridae, which all contain a glycosylation ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2017.11.026
更新日期:2018-04-01 00:00:00
abstract::Clade 2.3.4.4 H5N8 highly pathogenic avian influenza viruses (HPAIVs) have spread worldwide. Phylogenetic analysis identified two genetic groups of the H5N8 HPAIVs in South Korea; group A evolved further into four subgroups. Here, we examined the zoonotic potential, both in vivo and in vitro, of genetically distinct s...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2017.12.037
更新日期:2018-03-01 00:00:00
abstract::Cardioviruses cause diseases in many animals including, in rare cases, humans. Although they share common features with all picornaviruses, cardioviruses have unique properties that distinguish them from other family members, including enteroviruses. One feature shared by all picornaviruses is the covalent attachment ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.01.010
更新日期:2018-03-01 00:00:00
abstract::Marek's disease virus (MDV) is an oncogenic alphaherpesvirus of Gallus gallus, the domesticated chicken. Control strategies rely upon vaccination with live attenuated viruses of antigenically similar avian herpesviruses or attenuated strains of MDV. Recent studies in other viruses have shown that recoding certain vira...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.01.020
更新日期:2018-03-01 00:00:00
abstract::Mannose binding lectin (MBL) generally plays a protective role during viral infection, yet MBL-mediated complement activation promotes Ross River virus (RRV)-induced inflammatory tissue destruction, contributing to arthritis and myositis. As MBL binds to carbohydrates, we hypothesized that N-linked glycans on the RRV ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2017.12.022
更新日期:2018-02-01 00:00:00